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Supercritical Fluid Chromatography

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Overview

Sepiatec preparative Supercritical Fluid Chromatography (SFC) technology

Sepiatec designs compact and  very easy to use preparative SFC systems featuring an Integrated computer with a  TFT touch-screen placed in an ergonomically favorable position on the front of the unit and a new gas-liquid separation technology.

The Prep SFC 100 is a compact benchtop unit and an ideal upgrade path for older prep SFC systems that need replacement.

The Prep SFC 360 system represents a powerful solution for preparative separations by means of supercritical fluid chromatography. The unit has been designed for flow rates of up to 360 ml of supercritical fluid per minute. Depending on the modifier portion, even up to 600 ml/min may be achieved.

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Preparative Supercritical Fluid Chromatography (pSFC)

As an environment-friendly approach to purification applications, pSFC is being used routinely for an increasing number of applications.

During the recent years SFC has gained acceptance in drug discovery for high-throughput purification of enantiomers. Hence, pSFC replaces preparative HPLC (pHPLC) as major technology for chiral separations in many pharmaceutical companies. Preparative SFC excels not only at separating and purifying chiral compounds but is also powerful for achiral separations and can be implemented in most steps of drug discovery. It may offer potential advantages over pHPLC for purity upgrading of active pharmaceutical ingredients or drug intermediates, impurity isolation and non-aqueous purification.

The use of pSFC as an alternative option to pHPLC receives also a growing interest for natural products, environmental (pesticides) and petroleum (biofuels) applications.

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Sepiatec Prep SFC 100 system
A compact benchtop unit designed for preparative separation using supercritical fluid chromatography. Separation columns with inner diameters between 20 and 30 mm and a length of up to 250 mm can be used.

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Sepiatec Prep SFC 360 system
The system represents a powerful solution for preparative separations by means of supercritical fluid chromatography. Separation columns with inner diameters between 25 and 50 mm and a length of up to 800 mm can be used.

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Articles

Preparative Supercritical Fluid Chromatography (pSFC)

As an environment-friendly approach to purification applications, pSFC is being used routinely for an increasing number of applications.

During the recent years SFC has gained acceptance in drug discovery for high-throughput purification of enantiomers. Hence, pSFC replaces preparative HPLC (pHPLC) as major technology for chiral separations in many pharmaceutical companies. Preparative SFC excels not only at separating and purifying chiral compounds but is also powerful for achiral separations and can be implemented in most steps of drug discovery. It may offer potential advantages over pHPLC for purity upgrading of active pharmaceutical ingredients or drug intermediates, impurity isolation and non-aqueous purification.

The use of pSFC as an alternative option to pHPLC receives also a growing interest for natural products, environmental (pesticides) and petroleum (biofuels) applications.

Read more >>
Application notes

SFC measurement of fatty acid methyl esters and triglycerides in biodiesel fuel with charged aerosol detector
In this application, Jasco applied Supercritical Fluid Chromatography (SFC) coupled with CAD to an analysis of biodiesel fuel.

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PDF icon Download Application note, Separation of basic drugs by Supercritical Fluid Chromatography.pdf (377.12 KB)
Separation of basic drugs by Supercritical Fluid Chromatography
Date of creation: 
7 July 2017
Library code: 
11043
PDF icon Download Application note, Determination of olefin content of gasoline by SFC.pdf (509.86 KB)
Determination of olefin content of gasoline by SFC
Date of creation: 
7 July 2017
Library code: 
11041
PDF icon Download Application note, Determination of non-aromatic and aromatic hydrocarbon contents of diesel fuels by SFC.pdf (330.96 KB)
Determination of non-aromatic and aromatic hydrocarbon contents of diesel fuels by SFC
Date of creation: 
7 July 2017
Library code: 
11049
PDF icon Download Application note, Preparative purification of flavanone by semi-preparative UFC system and Cyclone Separator-87 (CS-87).pdf (101.73 KB)
Preparative purification of flavanone by semi-preparative UFC system and Cyclone Separator-87 (CS-87)
Date of creation: 
28 June 2017
Library code: 
11039
PDF icon Download Application note, Investigation of chiral separation conditions of cetirizine by UFC Methods Scouting System.pdf (200.05 KB)
Investigation of chiral separation conditions of cetirizine by UFC Methods Scouting System
Date of creation: 
28 June 2017
Library code: 
11038
PDF icon Download Application note, Investigation of chiral separation conditions of zopiclone by UFC Methods Scouting System.pdf (194.72 KB)
Investigation of chiral separation conditions of zopiclone by UFC Methods Scouting System
Date of creation: 
28 June 2017
Library code: 
11037
PDF icon Download Application note, Investigation of chiral separation conditions of bupivacaine by UFC Methods Scouting System.pdf (195.59 KB)
Investigation of chiral separation conditions of bupivacaine by UFC Methods Scouting System
Date of creation: 
28 June 2017
Library code: 
11036
PDF icon Download Application note, Investigation of chiral separation conditions of omeprazole by UFC Methods Scouting System.pdf (192.61 KB)
Investigation of chiral separation conditions of omeprazole by unified fluid chromatography Methods Scouting System
Date of creation: 
28 June 2017
Library code: 
11035
PDF icon Download Application note, Investigation of chiral separation conditions of warfarine by UFC Methods Scouting System.pdf (195.21 KB)
Investigation of chiral separation conditions of warfarine by UFC Methods Scouting System
Date of creation: 
28 June 2017
Library code: 
11034
Literature

Sepiatec Prep SFC 100 system
A compact benchtop unit designed for preparative separation using supercritical fluid chromatography. Separation columns with inner diameters between 20 and 30 mm and a length of up to 250 mm can be used.

Read more >>
PDF icon Download Brochure, Sepiatec PREP SFC 360 system.pdf (1.95 MB)
Sepiatec PREP SFC 360 system
Date of creation: 
4 November 2015
Library code: 
10393
PDF icon Download Catalog, Sepax Supercritical Fluid Chromatography (SFC) columns.pdf (2.17 MB)
Sepax Supercritical Fluid Chromatography (SFC) columns
Date of creation: 
20 July 2017
Library code: 
11110