Preparative Supercritical Fluid Chromatography (pSFC)
As an environment-friendly approach to purification applications, pSFC is being used routinely for an increasing number of applications.
During the recent years SFC has gained acceptance in drug discovery for high-throughput purification of enantiomers. Hence, pSFC replaces preparative HPLC (pHPLC) as major technology for chiral separations in many pharmaceutical companies. Preparative SFC excels not only at separating and purifying chiral compounds but is also powerful for achiral separations and can be implemented in most steps of drug discovery. It may offer potential advantages over pHPLC for purity upgrading of active pharmaceutical ingredients or drug intermediates, impurity isolation and non-aqueous purification.
The use of pSFC as an alternative option to pHPLC receives also a growing interest for natural products, environmental (pesticides) and petroleum (biofuels) applications.