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Biotage metal scavengers

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Overview

Metal scavengers in process chemistry
Metal scavengers were first investigated for contamination by independently confirmed ICP metal analysis methods. Additionally, these scavengers were extracted in a range of common solvents in order to show extractable and leachable levels. A metal scavenging reaction comparing API product yield, purity and also metal removal using metal scavengers was compared to corresponding carbon methods.

Biotage metal scavenging toolkit
The Biotage metal scavenging toolkit is an essential tool that can enable you to quickly and efficiently find the right metal scavenger for your application. Containing protocols, guidance and recommendations for working in batch mode or passing solutions through a fixed bed, this all in one kit showcases the metal scavengers and provides practical information on how to use the metal scavengers in your application for the best results.

Biotage metal scavenger user guide
This user guide gives useful information on the Biotage metal scavengers, including: case studies, methods and advantages of the metal scavengers. It has selection guides to help the user choose the right product for their needs.

Biotage industrial product portfolio
The Biotage 
portfolio of industrial scale products have a proven track record of successful applications and use in scale-up projects. The industrial product range can support the discovery, development and manufacturing of customer pharmaceutical and biotechnology products, from pre-clinical, phase I, II and III to small scale commercial operations.

Biotage ISOLUTE Si Trisamine metal scavenger
The Biotage ISOLUTE Si-Trisamine is a silica bound equivalent of a trisamine base and can scavenge a variety of electrophiles, including aldehydes, acid chlorides, sulfonyl chlorides, isocyanates, isothiocyanates and heavy metal ions such as Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Pb+2, Ru+2 and Zn2+. Si-Trisamine has a number of uses, it is a very powerful scavenger of transition metals and can also be used as a work-up tool to remove electrophiles or acids in either batch or flow-mode (cartridge) following traditional reflux heated or microwave synthesized reactions.

Biotage MP-TMT palladium scavenger
The Biotage MP-TMT is a macroporous polystyrene-bound trimercaptotriazine, a resin bound equivalent of 2,4,6-trimercaptotriazine (TMT). MP-TMT scavengers residual palladium from palladium catalyzed reactions and has also shown to remove other metals. The MP-base copolymer has been designed to yield a robust, low swelling material, which makes it ideal for restricted volume environments. Its unique pore structure provides greater access to the reactive sites resulting in faster reactions and higher recoveries.

Biotage ISOLUTE Si-TMT metal scavenger
The Biotage ISOLUTE Si-TMT is the silica bound equivalent of 2,4,6-trimer- captotriazine (TMT). Si-TMT has been shown to efficiently scavenge residual palladium from palladium-catalyzed reactions. The function group in Si-TMT is attached to a bioanalytical grade silica platform, thus the use of this material does not introduce impurities to the reaction system. There are numerous advantages of functionalized Isolute Silica.

Biotage ISOLUTE Si-Thiol metal scavenger
The Biotage ISOLUTE Si-Thiol is the silica-bound equivalent of 1-propane-thiol which is primarily used in the pharmaceutical industry as a metal scavenger for metals such as Pd, Pt, Cu, Hg, Ag and Pb, but it can also be useful for covalent scavenging of alkyl, benzyl and allyl halides as well as a variety of other electrophiles including acid chlorides and isocyanates.

Biotage ISOLUTE Si-Propylsulfonic Acid (SCX-2) metal scavenger
The Biotage ISOLUTE Si-Propylsulfonic Acid (SCX-2) belongs to a class of strong supported acids. As a bound sulfonic acid, it has a natural propensity to bind alkali and some transition metal group metals, which means that it can be used as a scavenger for metals with a +I or +II oxidation state, such as Na, K, Li, also Pd, Rh, and Ru. SCX-2 is typically used as a metal scavenger when the target product is not basic, to avoid the obvious acid/ base product binding interactions with the scavenger.

Application notes

Developing a scalable metals removal process using metal scavengers
This application note demonstrates the practical application of metal scavenging in the removal of palladium from a model active pharmaceutical ingredient (API).

Metal scavengers in process chemistry
Date of creation: 
28 March 2019
Library code: 
12417
Ruthenium scavenging applications
Date of creation: 
28 March 2019
Library code: 
12412
Metal mitigation, extractables and regulatory perspectives
Date of creation: 
28 March 2019
Library code: 
12410