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Cleaning in Place (CIP) testing

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Overview article
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Date of creation: 
17 November 2015
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The Cleaning in Place (CIP) process is aimed at removing any residual substances in manufacturing facilities and equipment (tanks, vessels, pipework) in various processing industries such as the pharmaceutical area. The CIP efficiency is critical to the overall production quality and must meet strict regulations while minimizing downtime between product runs or product changeover.


Teledyne Tekmar Total Organic Carbon (TOC) analyzers have found wide acceptance in the pharmaceutical and biotechnology industry to assist in the validation cleaning procedures, especially clean-in-place (CIP). TOC concentration levels can be used to track the success of these cleaning procedures.


The Alpha MOS HERACLES Electronic Nose is another option to answer the need for a fast, sensitive and reliable analysis method, and can be used to detect and quantify residual substances in cleaning solutions in the pharmaceutical industry.