Deaerating methods

Deaerating is the process of removing dissolved gasses from a material, typically a liquid. Due to the nature of diffusion cells, the formation of bubbles can be a major concern. Most bubbles will move up and can potentially block a portion of the membrane; reducing the area for the drug to diffuse through. There are methods both during preparation and in some cases during the test to deal with bubbles within diffusion cells.

This technical note provides information on the methods of deaeration, and choosing the best one for each situation.